when to treat chondral lesions in knee

Are chondral lesions symptomatic/ big enough and located on weigth bearing surface? Age of patient to predict if regeneration/ biologics or partial or full replacement are the options if regeneration osteoarticular plugs like mosaic or OATS which is the only Hyaline cartilage available or ACI(autologous cartilage implantaion)/Autocart/ Mesemchymal stem cell soaked scaffolds which produce next best hyaline like cartilage is advisable Micro/nanofracture which was the traditional method in the past have gone into disrepute due fibrocartilage which fails by 5 years and damaging irrevesible changes in the subchondral bone (cysts , intralesional osteophytes etc).