Another biological solution to buy time

 Stromal vascular fraction

Adipose derived stem cell has been used for some time in Plastic surgery and Orthopedics. Its use in joint preservation is increased due to its beneficial effects and to delay or ? avoid knee replacement.  Chondro-protective effects such as chondrocyte proliferation and cartilage matrix protection due to its paracrine actions have been proved in murine models for over a decade

Y.G Koh (KSSTA 2013), on second-look arthroscopy, 87.5 % of elderly patients (14/16) improved or maintained cartilage status at least 2 years post-operatively. No one underwent total knee arthroplasty during this 2-year period.  J. Pak, Int J Mol Sci. 2018 Jul; 19(7):  were among the first to report  injection of adipose derived stem cell as a single harvest and implantation as a medical procedure where are others lab cultured the cells and implanted higher  quantity to as a pharmaceutical product.

 We have been using the same SVF  for close to an year with good functional improvement in young arthritic patients or patients who wants to  avoid or delay knee replacement. In india, at present  cultured adipocyte are not permitted  and  we harvest stems from 60 cc of liposuction, centrifuges as per standard recommendations  and mix with PRP to inject into the knees.